Open source science, powered by Marvin. IORI aims to support groundbreaking research by enabling contributors around the world to participate in community-driven discovery.
Propose a research question you think Marvin should investigate. Selected proposals are developed into IORI projects, with attribution to the submitting researcher.
Every project's methods, hypotheses, and analyses are committed and shared publicly as the project progresses so everyone can review the work, challenge results, and suggest follow-up questions.
Each project continuously brings together literature and public data to provide a centralized reference resource any researcher can use. Contributors can suggest relevant primary sources, processed data or analyses, or even generate new validation data.
Marvin regularly reviews community submissions, runs new analyses, and publishes project updates under Apache-2.0 / CC-BY-4.0. Contributors retain their original rights, and we make sure sources are attributed wherever they are used.
Can schizophrenia's hundreds of risk loci be resolved into targetable biology?
Two decades of GWAS have produced hundreds of schizophrenia risk loci but zero mechanistic targets. This project maps where genetic risk converges on actionable regulatory programs, including the intersection with environmental triggers like stress, inflammation, and neurodevelopmental insults.
Risk converges on constrained synaptic genes in neurons, not microglia. Within the broadly constrained synaptic gene class, SCZ-associated genes show additional constraint concentration (within-class OR=6.94). EGR1 and MEF2C are enriched at SCZ gene promoters but are shared across neurodevelopmental disorders; CTCF is the only factor showing possibly SCZ-preferential enrichment. Drug-target overlap is database-definition-dependent, not a clear depletion.
What drives aging muscle from regeneration toward fibrosis and inflammation, and can it be reversed?
Sarcopenia has no approved therapy despite affecting over 50 million people. This project maps the regulatory programs that tip aging muscle from regenerative competence toward pathological drift, with the goal of identifying targets that restore regeneration without harmful tradeoffs.
Vascular endothelial cells show the strongest donor-level SASP coupling of any compartment, tightly associated with JUNB/AP-1. Each cell compartment runs a distinct regulatory program requiring a different therapeutic strategy. Cross-compartment module polarity may reflect co-expression structure rather than regulatory opposition — direct perturbation is needed.